Affordable Access

Sensory responses of human skin to synthetic histamine analogues and histamine.

Authors
  • Davies, M G
  • Greaves, M W
Type
Published Article
Journal
British journal of clinical pharmacology
Publication Date
May 01, 1980
Volume
9
Issue
5
Pages
461–465
Identifiers
PMID: 6446929
Source
Medline
License
Unknown

Abstract

The potential for itch production in human skin of the synthetic analogues of histamine, 2-methyl histamine (an H1-receptor agonist) and 4-methyl histamine and dimaprit (H2-receptor agonists) has been studied in vivo and compared with histamine. Itch thresholds for 2-methyl histamine were consistently much higher than for histamine (P < 0.001). The H1-receptor antagonist chlorpheniramine raised the itch thresholds to 2-methyl histamine and histamine significantly (P < 0.001). Pruritus was not obtained with either 4-methyl histamine or dimaprit. No evidence of synergism between 2-methyl histamine and either 4-methyl histamine or dimaprit was found. The results suggest that histamine-induced pruritus is mediated in part through the H1-receptor and in part via an additional (but probably non-H2) mechanism.

Report this publication

Statistics

Seen <100 times