Affordable Access

Sensitivity of melanoma cell lines to natural killer cells: a role for oncogene-modulated HLA class I expression?

Authors
Type
Published Article
Journal
Seminars in cancer biology
Publication Date
Volume
2
Issue
1
Pages
73–83
Identifiers
PMID: 1912519
Source
Medline
License
Unknown

Abstract

N-ras and c-myc oncogenes were found to be activated in melanoma. High c-myc expression renders melanoma cell lines sensitive to lysis by natural killer (NK) cells. This effect is mediated by locus-specific downmodulation of HLA-B expression by c-myc. Cell lines with a mutation in the N-ras gene were relatively sensitive to NK cells irrespective of HLA class I expression. These findings indicate that NK cells can kill tumor cells with activated myc or ras oncogenes in various ways, thus providing potential mechanisms to eliminate cancer cells with an activation of these oncogenes.

Statistics

Seen <100 times