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Sensitive quantification of carbon monoxide in vivo reveals a protective role of circulating hemoglobin in CO intoxication

Authors
  • Mao, Qiyue1
  • Kawaguchi, Akira T.2
  • Mizobata, Shun1
  • Motterlini, Roberto3
  • Foresti, Roberta3
  • Kitagishi, Hiroaki1
  • 1 Doshisha University, Kyotanabe, Kyoto, Japan , Kyotanabe (Japan)
  • 2 Tokai University, Isehara, Kanagawa, Japan , Isehara (Japan)
  • 3 University Paris Est Creteil, INSERM, IMRB, Creteil, France , Creteil (France)
Type
Published Article
Journal
Communications Biology
Publisher
Nature Publishing Group UK
Publication Date
Mar 29, 2021
Volume
4
Issue
1
Identifiers
DOI: 10.1038/s42003-021-01880-1
Source
Springer Nature
License
Green

Abstract

Mao et al. report highly sensitive quantification of carbon monoxide with a simple colorimetric assay, exploiting a synthetic supramolecular compound, hemoCD1. It can reveal distribution of CO in organs including the brain and can also serve as a CO scavenger for residual CO accumulated in organs. Finally, the authors showed circulating hemoglobin plays a protective role in CO intoxication.

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