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Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination

Authors
  • Xi, Xiaobo
  • Ye, Tong
  • Wang, Shuang
  • Na, Xiangming
  • Wang, Jianghua
  • Qing, Shuang
  • Gao, Xiaoyong
  • Wang, Changlong
  • Li, Feng
  • Wei, Wei
  • Ma, Guanghui
Publication Date
May 01, 2020
Source
Institutional Repository of Institute of Process Engineering, CAS (IPE-IR)
Keywords
License
Unknown
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Abstract

Therapeutic cancer vaccines that harness the immune system to reject cancer cells have shown great promise for cancer treatment. Although a wave of efforts have spurred to improve the therapeutic effect, unfavorable immunization microenvironment along with a complicated preparation process and frequent vaccinations substantially compromise the performance. Here, we report a novel microcapsule-based formulation for high-performance cancer vaccinations. The special self-healing feature provides a mild and efficient paradigm for antigen microencapsulation. After vaccination, these microcapsules create a favorable immunization microenvironment in situ, wherein antigen release kinetics, recruited cell behavior, and acid surrounding work in a synergetic manner. In this case, we can effectively increase the antigen utilization, improve the antigen presentation, and activate antigen presenting cells. As a result, effective T cell response, potent tumor inhibition, antimetastatic effects, and prevention of postsurgical recurrence are achieved with various types of antigens, while neoantigen was encapsuled and evaluated in different tumor models.

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