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Self-assembly of penta-selenopeptides into amyloid fibrils

Authors
  • GOKULA, RP
  • MAHATO, J
  • SINGH, HB
  • CHOWDHURY, A
Publication Date
Dec 03, 2018
Source
DSpace at IIT Bombay
Keywords
License
Unknown
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Abstract

Here, we report the synthesis of a penta-selenopeptide consisting of five benzyl protected selenocysteine residues. This selenopeptide was well characterized by both one- and two-dimensional (D) NMR spectroscopies. We find that the solution conformation is enriched with -sheet structures, which have a propensity to self-assemble and form amyloid fibrils.

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