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Self perception in bacteria: quorum sensing with acylated homoserine lactones.

Authors
  • Fuqua, C
  • Greenberg, E P
Type
Published Article
Journal
Current Opinion in Microbiology
Publisher
Elsevier
Publication Date
Apr 01, 1998
Volume
1
Issue
2
Pages
183–189
Identifiers
PMID: 10066485
Source
Medline
License
Unknown

Abstract

A variety of Gram-negative bacteria produce membrane permeant, acylated homoserine lactone (HL) pheromones that act as cell density cues. Synthesis and response to these factors requires proteins homologous to the Luxl acylhomoserine lactone synthase and the LuxR transcription factor from Vibrio fischeri. Recent genetic and biochemical studies have begun to provide a mechanistic understanding of acyl HL dependent gene regulation. Examination of the role of acyl HLs in diverse bacteria positions LuxR-Luxl type systems within an increasingly broad regulatory context and suggests that, in some bacteria, they comprise a global regulatory circuit.

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