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Selective lymphocyte inhibition by FTY720 slows the progressive course of chronic anti-thy 1 glomerulosclerosis.

Authors
  • Peters, Harm1
  • Martini, Sebastian
  • Wang, Yingrui
  • Shimizu, Fuijo
  • Kawachi, Hiroshi
  • Krämer, Stephanie
  • Neumayer, Hans-H
  • 1 Department of Nephrology and Center of Cardiovascular Research, Charité, University Medicine Berlin, Charité Campus Mitte, Humboldt University, Berlin, Germany. [email protected]
Type
Published Article
Journal
Kidney international
Publication Date
October 2004
Volume
66
Issue
4
Pages
1434–1443
Identifiers
PMID: 15458436
Source
Medline
License
Unknown

Abstract

Lymphocyte depletion by FTY720 limits the progression of anti-thy 1-induced glomerulosclerosis toward chronic tubulointerstitial fibrosis and renal insufficiency. The data suggest that lymphocytes actively participate in the progression of chronic experimental kidney disease, and that FTY720 may be a novel approach to slow the progressive course of human chronic renal diseases.

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