Affordable Access

Selective inhibition of low affinity IgE receptor (CD23) processing.

Authors
  • Bailey, S
  • Bolognese, B
  • Buckle, D R
  • Faller, A
  • Jackson, S
  • Louis-Flamberg, P
  • McCord, M
  • Mayer, R J
  • Marshall, L A
  • Smith, D G
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Jan 06, 1998
Volume
8
Issue
1
Pages
29–34
Identifiers
PMID: 9871623
Source
Medline
License
Unknown

Abstract

A series of hydroxamic acids related to the non-selective matrix metalloproteinase inhibitor Batimastat has been prepared, some members of which are potent inhibitors of the processing of the low affinity IgE receptor (CD 23). Increased activity is obtained by appropriate substitution at the alpha-position, whilst selectivity is gained by use of a P1' benzyl group in conjunction with a C-terminal primary amide.

Report this publication

Statistics

Seen <100 times