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Selective impairment of T lymphocyte activation following contact sensitization with oxazolone.

Authors
  • Kimber, I
  • Foster, J R
  • Baker, D
  • Turk, J L
Type
Published Article
Journal
International archives of allergy and applied immunology
Publication Date
Jan 01, 1991
Volume
95
Issue
2-3
Pages
142–148
Identifiers
PMID: 1937916
Source
Medline
License
Unknown

Abstract

We have previously reported that topical exposure of mice to oxazolone results in the appearance of regulatory mechanisms which markedly depress lymph node cell (LNC) proliferative responses to subsequent challenge with the same chemical. In the present study, we have sought to identify the cellular targets for such immunoregulation. Autoradiographic analyses revealed that although pre-exposure to oxazolone caused a substantial reduction of paracortical hyperplasia following challenge, the frequency of proliferating cells in lymphoid follicles was slightly increased. That B lymphocyte responses are unaffected by oxazolone-induced immunoregulation was confirmed by investigation of anti-hapten antibody formation by draining LNC. Challenge with oxazolone resulted in an accelerated antibody response in mice previously exposed to the same chemical. These data reveal that the active immunoregulation induced following sensitization with oxazolone is selective for T lymphocytes. Evidence is presented that CD4+ and CD8+ T lymphocytes possess equivalent sensitivity to these mechanisms.

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