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Selective activation of calcium permeability by aspartate in Purkinje cells.

Authors
  • Yuzaki, M
  • Forrest, D
  • Curran, T
  • Connor, J A
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Aug 23, 1996
Volume
273
Issue
5278
Pages
1112–1114
Identifiers
PMID: 8688099
Source
Medline
License
Unknown

Abstract

Glutamate and aspartate are endogenous excitatory amino acid neurotransmitters widely distributed in the mammalian central nervous system. Aspartate was shown to induce a large membrane current sensitive to N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists in Purkinje cells from mice lacking functional NMDA receptors (NR1(-/-)). This response was accompanied by high permeability to calcium. In contrast, no current was induced by aspartate in hippocampal neurons and cerebellar granule cells from NR1(-/-) mice. Several other glutamate receptor agonists failed to evoke this response. Thus, in Purkinje cells, aspartate activates a distinct response capable of contributing to synaptic plasticity through calcium permeability.

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