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Selection of resistant mutants of Citrobacter freundii by second and third-generation cephalosporins and imipenem.

Authors
  • del Rosario Valencia, A M
  • Vuye, A
  • Pijck, J
Type
Published Article
Journal
Infection
Publication Date
Jan 01, 1984
Volume
12
Issue
6
Pages
402–404
Identifiers
PMID: 6335134
Source
Medline
License
Unknown

Abstract

Using a single-step selection procedure, resistant mutants could be obtained from three clinical isolates of Citrobacter freundii with two second-generation and four third-generation cephalosporins but not with imipenem. All mutants showed a drastically increased beta-lactamase activity and were cross-resistant to all the cephalosporins examined. Combinations of cloxacillin with the cephalosporins were markedly synergistic, suggesting the principal role of the cephalosporinase in the resistance of these mutants.

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