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Seeing the unseen: the hidden world of slow axonal transport.

Authors
Type
Published Article
Journal
The Neuroscientist
1089-4098
Publisher
SAGE Publications
Publication Date
Volume
20
Issue
1
Pages
71–81
Identifiers
DOI: 10.1177/1073858413498306
PMID: 23912032
Source
Medline
Keywords
License
Unknown

Abstract

Axonal transport is the lifeline of axons and synapses. After synthesis in neuronal cell bodies, proteins are conveyed into axons in two distinct rate classes-fast and slow axonal transport. Whereas fast transport delivers vesicular cargoes, slow transport carries cytoskeletal and cytosolic (or soluble) proteins that have critical roles in neuronal structure and function. Although significant progress has been made in dissecting the molecular mechanisms of fast vesicle transport, mechanisms of slow axonal transport are less clear. Why is this so? Historically, conceptual advances in the axonal transport field have paralleled innovations in imaging the movement, and slow-transport cargoes are not as readily seen as motile vesicles. However, new ways of visualizing slow transport have reenergized the field, leading to fundamental insights that have changed our views on axonal transport, motor regulation, and intracellular trafficking in general. This review first summarizes classic studies that characterized axonal transport, and then discusses recent technical and conceptual advances in slow axonal transport that have provided insights into some long-standing mysteries.

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