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[Secretion of immunoglobulins in malignant melanoma of the skin].

Authors
Type
Published Article
Journal
Voprosy onkologii
Publication Date
Volume
34
Issue
3
Pages
314–318
Identifiers
PMID: 3358294
Source
Medline
License
Unknown

Abstract

The study was concerned with the dynamics of correlations between IgA, IgM and IgG levels involved in pigmented neoplasm development in 154 cancer patients and 75 healthy subjects. The dynamics was found to represent stages of tumor development rather than changes in absolute indexes of serum immunoglobulin concentrations. The nature of changes in the structure of correlations suggested a possible switch from IgM to IgG and IgM to IgA secretion, i.e. disturbances in B-lymphocyte differentiation. Said changes were observed at a certain stage of melanoma progression, namely, during metastatic spreading.

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