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Secondary syphilis with an interstitial granuloma annulare-like histopathologic pattern.

Authors
  • Sezer, Engin
  • Luzar, Bostjan
  • Calonje, Eduardo
Type
Published Article
Journal
Journal of Cutaneous Pathology
Publisher
Wiley (Blackwell Publishing)
Publication Date
May 01, 2011
Volume
38
Issue
5
Pages
439–442
Identifiers
DOI: 10.1111/j.1600-0560.2010.01657.x
PMID: 21251035
Source
Medline
License
Unknown

Abstract

A granulomatous tissue response may be observed in untreated, long-standing lesions of secondary syphilis. In addition to poorly defined granulomatous inflammation, leprosy-like sarcoidal and palisaded granulomatous inflammation has been documented in literature reports of lues. Herein, we report a 47-year-old man who presented with a 3-month history of a generalized non-pruritic macular and papular rash located on the trunk and extremities. Histopathologically, there was an interstitial arrangement of histiocytes with occasional multinucleated giant cells positioned among collagen bundles without associated necrosis, thereby closely mimicking interstitial granuloma annulare. A clue to the diagnosis was the presence of admixed plasma cells. To the best of our knowledge, this is the first reported case of secondary syphilis showing an interstitial granulomatous pattern mimicking interstitial granuloma annulare.

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