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Secondary NK/T cell lymphoma after radiotherapy for non-HPV-related squamous cell carcinoma of the penis: an early warning event and literature review

Authors
  • Sun, Di
  • Yang, Ping
  • Zhang, Li
  • Jiang, Lei
  • Yu, Guohua
Type
Published Article
Journal
International journal of clinical and experimental pathology
Publication Date
Aug 01, 2020
Volume
13
Issue
8
Pages
2173–2180
Identifiers
PMID: 32922617
PMCID: PMC7476929
Source
PubMed Central
Keywords
License
Unknown

Abstract

Squamous cell carcinoma is the most common malignant tumor of the penis. The new World Health Organization (WHO) classifies it into two types: non-HPV-related and HPV-related. There is a certain proportion of recurrence and metastasis after the first operation on the tumor. Radiotherapy is one of the effective methods to improve prognosis, but there is a risk of secondary primary malignant tumor. Primary NK/T cell lymphoma of the penis is rare, and secondary primary NK/T cell lymphoma of penile stump after radiotherapy for penile cancer has not been reported. Here we report a case of a 75-year-old man who was diagnosed with primary non-HPV-related squamous cell carcinoma of the penis five years after the operation of gastric adenocarcinoma. One year after the first penile operation, penile cancer recurred with multiple metastases in the left inguinal lymph nodes, and radiotherapy was performed after re-operation. Secondary primary penile NK/T cell lymphoma was induced 16 months after radiotherapy. Secondary lymphoma after radiotherapy for penile cancer is an accidental event, and the efficacy and risk of postoperative radiotherapy need to be further evaluated.

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