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Acute Administration of Desformylflustrabromine Relieves Chemically Induced Pain in CD-1 Mice.

Authors
  • Weggel, Loni A1
  • Pandya, Anshul A2
  • 1 Department of Biosciences, College of Rural and Community Development, 101D Harper Building, 810 Draanjik Drive, University of Alaska Fairbanks, Fairbanks, AK 99709-3419, USA. [email protected]
  • 2 Department of Biosciences, College of Rural and Community Development, 101D Harper Building, 810 Draanjik Drive, University of Alaska Fairbanks, Fairbanks, AK 99709-3419, USA. [email protected]
Type
Published Article
Journal
Molecules
Publisher
MDPI AG
Publication Date
Mar 07, 2019
Volume
24
Issue
5
Identifiers
DOI: 10.3390/molecules24050944
PMID: 30866543
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Neuronal nicotinic acetylcholine receptors are cell membrane-bound ion channels that are widely distributed in the central nervous system. The α4β2 subtype of neuronal nicotinic acetylcholine receptor plays an important role in modulating the signaling pathways for pain. Previous studies have shown that agonists, partial agonists, and positive allosteric modulators for the α4β2 receptors are effective in relieving pain. Desformylflustrabromine is a compound that acts as an allosteric modulator of α4β2 receptors. The aim of this study was to assess the effects of desformylflustrabromine on chemically induced pain. For this purpose, the formalin-induced pain test and the acetic acid-induced writhing response test were carried out in CD-1 mice. Both tests represent chemical assays for nociception. The results show that desformylflustrabromine is effective in producing an analgesic effect in both tests used for assessing nociception. These results suggest that desformylflustrabromine has the potential to become a clinically used drug for pain relief.

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