Affordable Access

A second look at emepronium bromide in urinary incontinence.

Authors
Type
Published Article
Journal
Lancet (London, England)
Publication Date
Volume
1
Issue
8010
Pages
504–506
Identifiers
PMID: 65608
Source
Medline
License
Unknown

Abstract

Response to oral and intramuscular emepronium bromide was assessed cystometrically in nine patients with urinary incontinence caused by an uninhibited bladder. Oral therapy had no effect, whereas intramuscular administration increased bladder capacity and significantly delayed the onset of bladder spasm and the desire to void. Plasma-propranolol response was delayed and concentrations were reduced after an oral 40 mg dose of propranolol in 3 patients who had received oral emepronium bromide. These results indicate that although oral emepronium bromide had some anticholinergic effect--i.e., in reducing gastrointestinal motility--absorption of an oral dose was not sufficient for the bladder to be affected.

Statistics

Seen <100 times