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The Sec14-superfamily and the regulatory interface between phospholipid metabolism and membrane trafficking.

Authors
  • Mousley, Carl J
  • Tyeryar, Kimberly R
  • Vincent-Pope, Patrick
  • Bankaitis, Vytas A
Type
Published Article
Journal
Biochimica et Biophysica Acta
Publisher
Elsevier
Publication Date
Jun 01, 2007
Volume
1771
Issue
6
Pages
727–736
Identifiers
PMID: 17512778
Source
Medline
License
Unknown

Abstract

A central principle of signal transduction is the appropriate control of the process so that relevant signals can be detected with fine spatial and temporal resolution. In the case of lipid-mediated signaling, organization and metabolism of specific lipid mediators is an important aspect of such control. Herein, we review the emerging evidence regarding the roles of Sec14-like phosphatidylinositol transfer proteins (PITPs) in the action of intracellular signaling networks; particularly as these relate to membrane trafficking. Finally, we explore developing ideas regarding how Sec14-like PITPs execute biological function. As Sec14-like proteins define a protein superfamily with diverse lipid (or lipophile) binding capabilities, it is likely these under-investigated proteins will be ultimately demonstrated as a ubiquitously important set of biological regulators whose functions influence a large territory in the signaling landscape of eukaryotic cells.

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