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Seasonal prevalence of MS disease activity.

Authors
  • Meier, D S
  • Balashov, K E
  • Healy, B
  • Weiner, H L
  • Guttmann, C R G
Type
Published Article
Journal
Neurology
Publisher
Ovid Technologies (Wolters Kluwer) - American Academy of Neurology
Publication Date
Aug 31, 2010
Volume
75
Issue
9
Pages
799–806
Identifiers
DOI: 10.1212/WNL.0b013e3181f0734c
PMID: 20805526
Source
Medline
License
Unknown

Abstract

This study documents evidence of a strong seasonal pattern in subclinical MS activity based on noncontrast brain MRI. The observed seasonality in MS disease activity has implications for trial design and therapy assessment. The observed activity pattern is suggestive of a modulating role of seasonally changing environmental factors or season-dependent metabolic activity.

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