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A Search for subgroups of patients with ARDS who may benefit from surfactant replacement therapy: a pooled analysis of five studies with recombinant surfactant protein-C surfactant (Venticute).

Authors
  • Taut, Friedemann J H
  • Rippin, Gerd
  • Schenk, Peter
  • Findlay, George
  • Wurst, Wilhelm
  • Häfner, Dietrich
  • Lewis, James F
  • Seeger, Werner
  • Günther, Andreas
  • Spragg, Roger G
Type
Published Article
Journal
Chest
Publication Date
Oct 01, 2008
Volume
134
Issue
4
Pages
724–732
Identifiers
DOI: 10.1378/chest.08-0362
PMID: 18689599
Source
Medline
License
Unknown

Abstract

rSP-C surfactant improved oxygenation in patients with ARDS irrespective of the predisposition. Post hoc evidence of reduced mortality associated with surfactant treatment was obtained in patients with severe respiratory insufficiency due to pneumonia or aspiration. Those patients are the focus of a current randomized, blinded, clinical trial with rSP-C surfactant.

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