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The Scribble family in cancer: twentieth anniversary

Authors
  • Santoni, Marie-Josée1
  • Kashyap, Rudra1, 2
  • Camoin, Luc3
  • Borg, Jean-Paul1, 3, 4
  • 1 Aix Marseille Université, Inserm, CNRS, Institut Paoli-Calmettes,
  • 2 Katholisch University of Leuven,
  • 3 Institut Paoli-Calmettes, CRCM, Marseille Protéomique,
  • 4 Institut Universitaire de France (IUF),
Type
Published Article
Journal
Oncogene
Publisher
Nature Publishing Group UK
Publication Date
Sep 30, 2020
Pages
1–15
Identifiers
DOI: 10.1038/s41388-020-01478-7
PMID: 32999444
PMCID: PMC7527152
Source
PubMed Central
Keywords
License
Unknown

Abstract

Among the more than 160 PDZ containing proteins described in humans, the cytoplasmic scaffold Scribble stands out because of its essential role in many steps of cancer development and dissemination. Its fame has somehow blurred the importance of homologous proteins, Erbin and Lano, all belonging to the LRR and PDZ (LAP) protein family first described twenty years ago. In this review, we will retrace the history of LAP family protein research and draw attention to their contribution in cancer by detailing the features of its members at the structural and functional levels, and highlighting their shared—but also different—implication in the tumoral process.

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