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Screening, identification, and functional analysis of three novel missense mutations in the TRADD gene in children with ALL and ALPS.

Authors
  • Dechant, M J
  • Scheuerpflug, C G
  • Pauly, E
  • van der Werff Ten Bosch, J
  • Debatin, K M
  • Fellenberg, J
Type
Published Article
Journal
Pediatric Blood & Cancer
Publisher
Wiley (John Wiley & Sons)
Publication Date
Nov 01, 2008
Volume
51
Issue
5
Pages
616–620
Identifiers
DOI: 10.1002/pbc.21672
PMID: 18661484
Source
Medline
License
Unknown

Abstract

Mutations in the TRADD gene may contribute to the development of different hematological diseases. The identified mutations demonstrate a putative impact on TRADD signaling and cell survival but may not mainly explain the pathology of the diseases investigated.

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