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Screening of effective pharmacological treatments for MELAS syndrome using yeasts, fibroblasts and cybrid models of the disease.

Authors
Type
Published Article
Journal
British Journal of Pharmacology
1476-5381
Publisher
Wiley Blackwell (Blackwell Publishing)
Publication Date
Volume
167
Issue
6
Pages
1311–1328
Identifiers
DOI: 10.1111/j.1476-5381.2012.02086.x
PMID: 22747838
Source
Medline
License
Unknown

Abstract

Our results indicate that cell models have great potential for screening and validating the effects of novel drug candidates for MELAS treatment and presumably also for other diseases with mitochondrial impairment.

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