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Screening of effective pharmacological treatments for MELAS syndrome using yeasts, fibroblasts and cybrid models of the disease.

Authors
  • Garrido-Maraver, Juan
  • Cordero, Mario D
  • Moñino, Irene Domínguez
  • Pereira-Arenas, Sheila
  • Lechuga-Vieco, Ana V
  • Cotán, David
  • De la Mata, Mario
  • Oropesa-Ávila, Manuel
  • De Miguel, Manuel
  • Bautista Lorite, Juan
  • Rivas Infante, Eloy
  • Alvarez-Dolado, Manuel
  • Navas, Plácido
  • Jackson, Sandra
  • Francisci, Silvia
  • Sánchez-Alcázar, José A
Type
Published Article
Journal
British Journal of Pharmacology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Nov 01, 2012
Volume
167
Issue
6
Pages
1311–1328
Identifiers
DOI: 10.1111/j.1476-5381.2012.02086.x
PMID: 22747838
Source
Medline
License
Unknown

Abstract

Our results indicate that cell models have great potential for screening and validating the effects of novel drug candidates for MELAS treatment and presumably also for other diseases with mitochondrial impairment.

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