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Screening of antitumor polypeptide drug and enhanced CT imaging based on drug target analysis.

Authors
  • Shao, Chenghui1
  • Xu, Shuangshuang1
  • Song, Yang2
  • Zhu, Dong3
  • 1 College of Mechanical Science and Engineering, Jilin University, Jilin, China. , (China)
  • 2 School of Mechanical Engineering, Tianjin University of Technology, Tianjin, China. , (China)
  • 3 The First Hospital of Jilin University, Jilin, China. , (China)
Type
Published Article
Journal
Pakistan journal of pharmaceutical sciences
Publication Date
Sep 01, 2017
Volume
30
Issue
5(Special)
Pages
1883–1888
Identifiers
PMID: 29084661
Source
Medline
License
Unknown

Abstract

Molecular targeted antitumor drugs is a major progress in recent years, these drugs usually target specific molecules to tumor cell signaling pathways, reduce toxicity, and can achieve individualized treatment. In this study, we screened three polypeptide proteins by yeast two hybrid systems, which could inhibit tumor growth obviously. The results of this study are expected to further develop new antitumor drugs. Moreover, by using contrast-enhanced computed tomography (CECT) imaging, this study proposes an algorithm for the computer-aided diagnosis (CAD) and classification of adrenal tumors. The experimental results demonstrate an excellent classification performance of this algorithm. Therefore, the method proposed in this paper may accurately locate and qualitatively diagnose the adrenal tumor in an effective manner, thereby providing important references for treatment.

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