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Inflammasome: Putting the Pieces Together

Authors
  • Ruland, Jürgen
Type
Published Article
Journal
Cell
Publisher
Elsevier
Publication Date
Jan 01, 2014
Volume
156
Issue
6
Pages
1127–1129
Identifiers
DOI: 10.1016/j.cell.2014.02.038
Source
Elsevier
License
Unknown

Abstract

Microbial and danger signals result in inflammasome activation and release of inflammatory cytokines through mechanisms that remain elusive. Cai et al. and Lu et al. show that triggering of inflammasome sensors induces prion-like polymerization of the adaptor ASC into filaments. These structures function as platforms for inflammatory cytokine production and represent a unified mechanism for inflammasome assembly.

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