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Scientific basis for bilateral animal models in orthopaedics.

Authors
  • Laberge, M
  • Powers, D L
Type
Published Article
Journal
Journal of investigative surgery : the official journal of the Academy of Surgical Research
Publication Date
Jan 01, 1991
Volume
4
Issue
2
Pages
109–110
Identifiers
PMID: 2069921
Source
Medline
License
Unknown

Abstract

(1) Bilateral procedures should be used when weight-bearing is an experimental parameter that should be controlled. (2) Bilateral procedures should be used for biocompatibility in osseous tissue and in fact most tissues according to ASTM. (3) Bilateral models in orthopaedics allow a more objective evaluation and characterization of materials and implants, reducing statistical and biological variables by an order of magnitude. Thus, this experimental approach increases the statistical significance of a study with a smaller number of animals.

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