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Schistosoma mansoni: evaluation of the activity of oxamniquine on schistosomules, at 24 hours after infection.

Authors
  • Coelho, P M
  • de Mello, R T
  • Gerken, S E
Type
Published Article
Journal
Revista do Instituto de Medicina Tropical de São Paulo
Publisher
SciELO
Publication Date
Jan 01, 1993
Volume
35
Issue
6
Pages
557–561
Identifiers
PMID: 7997761
Source
Medline
License
Unknown

Abstract

Mice transcutaneously infected with about 400 cercariae were submitted to treatment with oxamniquine (400 mg/kg), 24 hours after infection. The recovery of schistosomules, at 4, 24, 48 and 72 hours and 35 days after treatment, showed the activity of the drug on the parasites, thus practically preventing their migration from the skin to the lungs. Worm recovery performed in the lungs (96 hours after treatment) showed recovery means of 0.6 worms/mouse in the treated group and 53.8 in the control group (untreated). The perfusion of the portal system carried out at 35 days after treatment clearly showed the elimination of all the parasites in the treated group, whereas a recovery mean of 144.7 worms/mouse was detected in the control group (untreated). These findings confirm the efficacy of oxamniquine at the skin phase of infection, and also show similarity with the immunization method that uses irradiated cercariae. The practical application of these findings in the medical clinic is discussed too.

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