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Scanning gel densitometry of amniotic fluid acetylcholinesterase and butyrylcholinesterase: quantification of 'faint-positive' bands in fetal malformations.

Authors
  • Dupont, M
  • Vallet, B
  • Brun, A
  • Boulot, P
  • Demaille, J
Type
Published Article
Journal
Biology of the neonate
Publication Date
Jan 01, 1995
Volume
67
Issue
4
Pages
244–247
Identifiers
PMID: 7647148
Source
Medline
License
Unknown

Abstract

The quantification of 'faint-positive' cholinesterases in amniotic fluid was performed in 40 patients with positive acetylcholinesterase (AchE) tests. Fetuses with anencephaly and open spina bifida presented an AchE/butyrylcholinesterase (A/B) ratio of more than 0.3 with clearly dense bands. Fetuses with gastroschisis showed a 'faint-positive' AchE band (A/B < 0.3). In 5 fetuses (1 teratoma, 3 open spina bifida, 1 unaffected) we found faint AchE and butyrylcholinesterase bands.

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