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SARS-CoV-2 reinfection and COVID-19 severity

Authors
  • Nguyen, Nhu Ngoc
  • Houhamdi, Linda
  • Hoang, Van Thuan
  • Delerce, Jeremy
  • Delorme, Léa
  • Colson, Philippe
  • Brouqui, Philippe
  • Fournier, Pierre-Edouard
  • Raoult, Didier
  • Gautret, Philippe
Type
Published Article
Journal
Emerging Microbes & Infections
Publisher
Taylor & Francis
Publication Date
Mar 21, 2022
Volume
11
Issue
1
Pages
894–901
Identifiers
DOI: 10.1080/22221751.2022.2052358
PMID: 35264078
PMCID: PMC8942490
Source
PubMed Central
Keywords
Disciplines
  • Research Article
License
Unknown

Abstract

SARS-CoV-2 reinfection rate is low. The relative severity of the first and second episodes of infection remains poorly studied. In this study, we aimed at assessing the frequency of SARS-CoV-2 reinfections and comparing the severity of the first and second episodes of infection. We retrospectively included patients with SARS-CoV-2 positive RT-PCR at least 90 days after clinical recovery from a COVID-19 episode and with at least one negative RT-PCR after the first infection. Whole genome sequencing and variant-specific RT-PCR were performed and clinical symptoms and severity of infection were retrospectively documented from medical files. A total of 209 COVID-19 reinfected patients were identified, accounting for 0.4% of positive cases diagnosed from 19 March 2020 to 24 August 2021. Serology was performed in 64 patients, of whom 39 (60.1%) had antibodies against SARS-CoV-2 when sampled at the early stage of their second infection. Only seven patients (3.4%) were infected twice with the same variant. We observed no differences in clinical presentation, hospitalization rate, and transfer to ICU when comparing the two episodes of infections. Our results suggest that the severity of the second episode of COVID-19 is in the same range as that of the first infection, including patients with antibodies.

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