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SARS-CoV-2 invasion of the central nervous: a brief review

Authors
  • Siddiqui, Ruqaiyyah1
  • Mungroo, Mohammad Ridwane2
  • Khan, Naveed Ahmed2
  • 1 American University of Sharjah, United Arab Emirates , (United Arab Emirates)
  • 2 College of Medicine, University of Sharjah, University City, United Arab Emirates , (United Arab Emirates)
Type
Published Article
Journal
Hospital Practice (1995)
Publisher
Taylor & Francis
Publication Date
Mar 01, 2021
Pages
1–7
Identifiers
DOI: 10.1080/21548331.2021.1887677
PMID: 33554684
PMCID: PMC7938650
Source
PubMed Central
Keywords
License
Unknown

Abstract

There is increasing evidence of the ability of the novel coronavirus to invade the central nervous system (CNS). But how does a respiratory virus invade the highly protected CNS? Here, we reviewed available literature and case reports to determine CNS involvement in COVID-19, and to identify potential regions of the brain that may be affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its possible route of entry into the brain to identify its pathogenicity. Based on the symptoms, the parietal lobe and the cerebellum are the likely targets of SARS-CoV-2; however, further work is needed to elucidate this. The presence of ACE2, used by SARS-CoV-2 for cell entry, in the brain as well as detection of the virus in the cerebrospinal fluid, further assert that SARS-COV-2 targets the brain, and therefore, medical practitioners should take that into account when dealing with patients suffering from COVID-19.

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