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SARS-COV-2 infection in pregnant women and newborns in a Spanish cohort (GESNEO-COVID) during the first wave

  • Carrasco, Itzíar1, 2
  • Muñoz-Chapuli, Mar3
  • Vigil-Vázquez, Sara3
  • Aguilera-Alonso, David1, 2, 3
  • Hernández, Concepción3
  • Sánchez-Sánchez, César3
  • Oliver, Cristina3
  • Riaza, Mónica4
  • Pareja, Marta5
  • Sanz, Olga6
  • Pérez-Seoane, Beatriz7
  • López, Juan8
  • Márquez, Elena9
  • Domínguez-Rodríguez, Sara10
  • Hernanz-Lobo, Alicia1, 2, 3
  • De León-Luis, Juan Antonio2, 3
  • Sánchez-Luna, Manuel2, 3
  • Navarro, María Luisa1, 2, 3
  • 1 Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain , Madrid (Spain)
  • 2 Facultad de Medicina Universidad Complutense de Madrid, Madrid, Spain , Madrid (Spain)
  • 3 Hospital General Universitario Gregorio Marañón, Madrid, Spain , Madrid (Spain)
  • 4 Hospital Universitario HM Montepríncipe, Madrid, Spain , Madrid (Spain)
  • 5 Hospital General de Albace, Castilla La Mancha, Spain , Castilla La Mancha (Spain)
  • 6 Complejo Hospitalario de Navarra, Navarra, Spain , Navarra (Spain)
  • 7 Hospital Universitario Infanta Sofía, Madrid, Spain , Madrid (Spain)
  • 8 Hospital Universitario Infanta Leonor, Madrid, Spain , Madrid (Spain)
  • 9 Department of Paediatrics, Hospital San Pedro de Alcántara, Cáceres, Spain , Cáceres (Spain)
  • 10 Paediatric Infectious Diseases Unit, Fundación para la Investigación Biomédica del Hospital 12 de Octubre, Madrid, Spain , Madrid (Spain)
Published Article
BMC Pregnancy and Childbirth
Springer (Biomed Central Ltd.)
Publication Date
Apr 26, 2021
DOI: 10.1186/s12884-021-03784-8
Springer Nature


BackgroundKnowledge about SARS-CoV-2 infection in pregnancy and newborns is scarce. The objective of this study is to analyse clinical and epidemiological characteristics of a cohort of women infected with SARS-CoV-2 during pregnancy and their newborns exposed to SARS-CoV-2 during gestation.MethodsMulticentric observational study of Spanish hospitals from the GESNEO-COVD cohort, participants in RECLIP (Spanish Network of Paediatric Clinical Assays). Women with confirmed SARS-CoV-2 infection by PCR and/or serology during pregnancy, diagnosed and delivering during the period 15/03/2020–31/07/2020 were included. Epidemiological, clinical, and analytical data was collected.ResultsA total of 105 pregnant women with a median of 34.1 years old (IQR: 28.8–37.1) and 107 newborns were included. Globally, almost 65% of pregnant women had some COVID-19 symptoms and more than 43% were treated for SARS-COV-2. Overall, 30.8% of pregnant women had pneumonia and 5 (4.8%) women were admitted to the intensive care unit needing invasive mechanical ventilation. There was a rate of 36.2% of caesarean sections, which was associated with pneumonia during pregnancy (OR: 4.203, CI 95%: 1.473–11.995) and lower gestational age at delivery (OR: 0.724, CI 95%: 0.578–0.906). The prevalence of preterm birth was 20.6% and prematurity was associated with pneumonia during gestation (OR: 6.970, CI95%: 2.340–22.750) and having a positive SARS-CoV-2 PCR at delivery (OR: 6.520, CI95%: 1.840–31.790). All nasopharyngeal PCR in newborns were negative at birth and one positivized at 15 days of life. Two newborns died, one due to causes related to prematurity and another of unexpected sudden death during early skin-to-skin contact after delivery.ConclusionsAlthough vertical transmission has not been reported in this cohort, the prognosis of newborns could be worsened by SARS-CoV-2 infection during pregnancy as COVID-19 pneumonia increased the risk of caesarean section deliveries and preterm births.

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