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SARS-CoV-2 infection in a patient with propionic acidemia

Authors
  • Caciotti, Anna1
  • Procopio, Elena2
  • Pochiero, Francesca2
  • Falliano, Silvia1
  • Indolfi, Giuseppe3
  • Donati, Maria Alice2
  • Ferri, Lorenzo1
  • Guerrini, Renzo1, 4
  • Morrone, Amelia1, 4
  • 1 A. Meyer Children’s Hospital, Viale Pieraccini n. 24, Florence, 50139, Italy , Florence (Italy)
  • 2 A. Meyer Children’s Hospital, Florence, Italy , Florence (Italy)
  • 3 Meyer Children’s University Hospital, Florence, Italy , Florence (Italy)
  • 4 University of Florence, Florence, Italy , Florence (Italy)
Type
Published Article
Journal
Orphanet Journal of Rare Diseases
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Oct 28, 2020
Volume
15
Issue
1
Identifiers
DOI: 10.1186/s13023-020-01563-w
Source
Springer Nature
Keywords
License
Green

Abstract

We describe a 14-month-old boy, with a previous diagnosis of propionic acidemia (PA) by expanded newborn screening, who, admitted for a suspected metabolic crisis, tested positive for SARS-CoV-2. Since propionic acidemia was diagnosed, the patient has followed the recommended diet for this inborn error of metabolism. Although propionic acidemia patients are at a high risk of suffering metabolic crises, frequently associated with permanent clinical complications, psychomotor development of this patient was normal. The SARS-CoV-2 infection (at about 1 year of age) caused the patient’s first metabolic crisis. However, his clinical course was in keeping with a mild clinical form of COVID-19, and he recovered without experiencing severe clinical consequences. We describe this patient in order to improve the knowledge about follow up of PA patients identified by newborn screening and to increase the limited number of reports of SARS-CoV-2 infection in children with comorbidities, especially inborn errors of metabolism.

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