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SARS-CoV-2 antibody testing-questions to be asked.

Authors
  • Özçürümez, Mustafa K1
  • Ambrosch, Andreas2
  • Frey, Oliver3
  • Haselmann, Verena4
  • Holdenrieder, Stefan5
  • Kiehntopf, Michael6
  • Neumaier, Michael4
  • Walter, Michael7
  • Wenzel, Folker8
  • Wölfel, Roman9
  • Renz, Harald10
  • 1 Department of Laboratory Medicine of the Medical Clinic at the University Medical Center Knappschaftskrankenhaus Bochum, Ruhr University, Bochum, Germany. Electronic address: musta[email protected] , (Germany)
  • 2 Institute of Laboratory Medicine, Microbiology and Hygiene, Barmherzige Brüder Hospital, Regensburg, Germany. , (Germany)
  • 3 Institute of Laboratory Medicine, Brandenburg Medical School, Brandenburg an der Havel, Germany; Institute of Medical Diagnostics, Berlin, Germany. , (Germany)
  • 4 Institute of Clinical Chemistry, University Medicine Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany. , (Germany)
  • 5 Institute for Laboratory Medicine, German Heart Centre, Technical University Munich, Munich, Germany. , (Germany)
  • 6 Department of Clinical Chemistry and Laboratory Medicine, Jena University Hospital, Jena, Germany. , (Germany)
  • 7 Institute of Clinical Chemistry and Laboratory Medicine, Rostock University Medical Center, Rostock, Germany; Institute of Laboratory Medicine, Clinical Chemistry, and Pathobiochemistry, Charité University Medical Center, Berlin, Germany. , (Germany)
  • 8 Faculty of Medical and Life Sciences, Hochschule Furtwangen, Furtwangen, Germany. , (Germany)
  • 9 Bundeswehr Institute of Microbiology, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. , (Germany)
  • 10 Institute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps Universität Marburg, German Center for Lung Research (DZL), Marburg, Germany. , (Germany)
Type
Published Article
Journal
The Journal of allergy and clinical immunology
Publication Date
Jul 01, 2020
Volume
146
Issue
1
Pages
35–43
Identifiers
DOI: 10.1016/j.jaci.2020.05.020
PMID: 32479758
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Severe acute respiratory syndrome coronavirus 2 infection and development of coronavirus disease 2019 presents a major health care challenge of global dimensions. Laboratory diagnostics of infected patients, and the assessment of immunity against severe acute respiratory syndrome coronavirus 2, presents a major cornerstone in handling the pandemic. Currently, there is an increase in demand for antibody testing and a large number of tests are already marketed or are in the late stage of development. However, the interpretation of test results depends on many variables and factors, including sensitivity, specificity, potential cross-reactivity and cross-protectivity, the diagnostic value of antibodies of different isotypes, and the use of antibody testing in identification of acutely ill patients or in epidemiological settings. In this article, the recently established COVID-19 Task Force of the German Society for Clinical Chemistry and Laboratory Medicine (DGKL) addresses these issues on the basis of currently available data sets in this rapidly moving field. Copyright © 2020 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

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