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Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Antibody Responses in Children With Multisystem Inflammatory Syndrome in Children (MIS-C) and Mild and Severe Coronavirus Disease 2019 (COVID-19).

Authors
  • Anderson, Elizabeth M1
  • Diorio, Caroline2, 3
  • Goodwin, Eileen C1
  • McNerney, Kevin O2, 3
  • Weirick, Madison E1
  • Gouma, Sigrid1
  • Bolton, Marcus J1
  • Arevalo, Claudia P1
  • Chase, Julie2, 4
  • Hicks, Philip1, 5
  • Manzoni, Tomaz B1
  • Baxter, Amy E6, 7
  • Andrea, Kurt P6, 7
  • Burudpakdee, Chakkapong2
  • Lee, Jessica H2
  • Vella, Laura A6, 7, 8
  • Henrickson, Sarah E9
  • Harris, Rebecca M10
  • Wherry, E John6, 7
  • Bates, Paul1, 11
  • And 4 more
  • 1 Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • 2 Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • 3 Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • 4 Department of Pediatrics, Division of Rheumatology, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • 5 School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • 6 Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • 7 Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • 8 Department of Pediatrics, Division of Infectious Diseases, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • 9 Department of Pediatrics, Division of Allergy and Immunology, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • 10 Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • 11 Penn Center for Research on Coronavirus and Other Emerging Pathogens, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Type
Published Article
Journal
Journal of the Pediatric Infectious Diseases Society
Publisher
Oxford University Press
Publication Date
May 28, 2021
Volume
10
Issue
5
Pages
669–673
Identifiers
DOI: 10.1093/jpids/piaa161
PMID: 33263756
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibody responses in children remain poorly characterized. Here, we show that pediatric patients with multisystem inflammatory syndrome in children (MIS-C) possess higher SARS-CoV-2 spike immunoglobulin G (IgG) titers compared with those with severe coronavirus disease 2019, likely reflecting a longer time since the onset of infection in MIS-C patients. © The Author(s) 2020. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: [email protected]

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