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Sarcolemmal cardiac K(ATP) channels as a target for the cardioprotective effects of the fluorine-containing pinacidil analogue, flocalin.

Authors
  • Voitychuk, Oleg I1
  • Strutynskyi, Ruslan B
  • Yagupolskii, Lev M
  • Tinker, Andrew
  • Moibenko, Olexiy O
  • Shuba, Yaroslav M
  • 1 International Center of Molecular Physiology NASU, Kyiv, Ukraine. , (Ukraine)
Type
Published Article
Journal
British Journal of Pharmacology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Feb 01, 2011
Volume
162
Issue
3
Pages
701–711
Identifiers
DOI: 10.1111/j.1476-5381.2010.01072.x
PMID: 20942816
Source
Medline
License
Unknown

Abstract

Flocalin induced potent cardioprotection by activating cardiac-type K(ATP) -channels with all the benefits of the presence of fluorine group in the drug structure: higher lipophilicity, decreased toxicity, resistance to oxidation and thermal degradation, decreased metabolism in the organism and prolonged therapeutic action.

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