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Sarcoidosis and calcium homeostasis disturbances—Do we know where we stand?

Authors
  • Gwadera, Łukasz1
  • Białas, Adam Jerzy1
  • Iwański, Mikołaj Aleksander1
  • Górski, Paweł1
  • Piotrowski, Wojciech Jerzy1
  • 1 Department of Pneumology and Allergy, Chair of Internal Medicine, Medical University of Lodz, Poland
Type
Published Article
Journal
Chronic Respiratory Disease
Publisher
SAGE Publications
Publication Date
Nov 13, 2019
Volume
16
Identifiers
DOI: 10.1177/1479973119878713
PMID: 31718265
PMCID: PMC6854763
Source
PubMed Central
Keywords
License
Unknown

Abstract

The majority of cases involving hypercalcemia in the setting of sarcoidosis are explained by the overproduction of calcitriol by activated macrophages. Vitamin D takes part in the regulation of granuloma formation. However, using vitamin D metabolites to assess the activity of the disease is still problematic, and its usefulness is disputable. In some cases, though, a calcium metabolism disorder could be a valuable tool (i.e. as a marker of extrathoracic sarcoidosis). Although sarcoidosis does not cause a decrease in bone mineral density, increased incidence of vertebral deformities is noted. Despite increasing knowledge about calcium homeostasis disorders in patients with sarcoidosis, there is still a need for clear guidelines regarding calcium and vitamin D supplementation in these patients.

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