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Sanguinarine inhibits growth of human cervical cancer cells through the induction of apoptosis.

Authors
Type
Published Article
Journal
Oncology Reports
1791-2431
Publisher
Spandidos Publications
Publication Date
Volume
28
Issue
6
Pages
2264–2270
Identifiers
DOI: 10.3892/or.2012.2024
PMID: 22965493
Source
Medline

Abstract

Sanguinarine, a natural benzophenanthridine alkaloid, has been shown to possess anticancer activity in vitro and in vivo. In the present study, we demonstrated that sanguinarine caused a dose-dependent inhibition of growth in HeLa and SiHa human cervical cancer cells, i.e., 2.43 µmol/l (IC50) in HeLa cells and 3.07 µmol/l in SiHa cells. Cell cycle analysis revealed that sanguinarine significantly increased the sub-G1 population, from 1.7 to 59.7% in HeLa cells and from 1.7 to 41.7% in SiHa cells. Sanguinarine caused a dose-dependent decrease in Bcl-2 and NF-κB protein expression and a significant increase in Bax protein expression. Our findings indicate that sanguinarine as an effective anticancer drug candidate inhibits the growth of cervical cancer cells through the induction of apoptosis.

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