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Stress-induced gastrointestinal motility is responsible for epileptic susceptibility

Authors
  • Nikiforova, Assia S.1
  • 1 Ex officio
Type
Published Article
Journal
Medical Hypotheses
Publisher
Elsevier
Publication Date
Jan 01, 2014
Accepted Date
Jan 21, 2014
Volume
82
Issue
4
Pages
442–451
Identifiers
DOI: 10.1016/j.mehy.2014.01.020
Source
Elsevier
License
Unknown

Abstract

In order to explain observations linking epileptic EEG patterns (3Hz spike wave complexes and β−γ activity of 25–40Hz) and the involuntary slow wave of the gut (3c/min) and colonic contractile electrical complexes (25–40c/min), the physiological and pathological electrographic patterns recorded from different anatomical structures were compared. The similarities in shape and pattern provided the basis to hypothesise that these waves exist as a continuum associated with different cell types and that stress induces high-force involuntary tonic contractions and resistance to the segmental rhythmic contractions of the gut’s circular muscles. As a consequence, electrographic patterns with a waveform of 3c/min and 25–40c/min are organised in the periphery and transmitted to the central nervous system via visceral afferents with the same shape. The electrical interactions between the adjacent neurons of the enteric network, as well as between the interconnected gut/brain neuronal circuits, facilitate synchronisation of neuronal activity by the frequencies of the stress-induced patterns. In this way, the peripherally organised electrographic patterns actively participate in creating epileptic susceptibility with expressed gut symptoms.

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