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Salt, shake, fuse--giant hybrid polymer/lipid vesicles through mechanically activated fusion.

Authors
  • Henderson, Ian M
  • Paxton, Walter F
Type
Published Article
Journal
Angewandte Chemie International Edition in English
Publisher
Wiley (John Wiley & Sons)
Publication Date
Mar 24, 2014
Volume
53
Issue
13
Pages
3372–3376
Identifiers
DOI: 10.1002/anie.201309433
PMID: 24554375
Source
Medline
Keywords
License
Unknown

Abstract

Large (200 nm) poly(ethylene oxide)-b-poly(butadiene) polymer vesicles fuse into giant (>1 μm) vesicles with mild agitation in dilute aqueous NaCl solutions. This unusual effect is attributed to the salt-induced contraction of the poly(ethylene oxide) corona, reducing steric resistance between vesicles and, with agitation, increasing the probability of contact between the hydrophobic cores of adjacent membranes. In addition, NaCl and agitation facilitated the creation of giant hybrid vesicles from much smaller homogeneous polymersomes and liposomes. Whereas lipid vesicles do not readily fuse with each other under the same circumstances, they did fuse with polymersomes to produce hybrid polymer/lipid vesicles.

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