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Salivary and hair cortisol as biomarkers of emotional and behavioral symptoms in 6-9 year old children.

Authors
  • Golub, Yulia1
  • Kuitunen-Paul, Sören2
  • Panaseth, Kerstin3
  • Stonawski, Valeska4
  • Frey, Stefan5
  • Steigleder, Ruth6
  • Grimm, Jennifer7
  • Goecke, Tamme W8
  • Fasching, Peter A9
  • Beckmann, Matthias W10
  • Kornhuber, Johannes11
  • Kratz, Oliver12
  • Heinrich, Hartmut13
  • Moll, Gunter H14
  • Eichler, Anna15
  • 1 University Hospital Erlangen, Department of Child and Adolescent Mental Health, Schwabachanlage 6 & 10, 91054 Erlangen, Germany; University Hospital Dresden, Department of Child and Adolescent Psychiatry and Psychotherapy, Fetscherstraße 74, 01307 Dresden, Germany. Electronic address: [email protected]dd.de. , (Germany)
  • 2 University Hospital Dresden, Department of Child and Adolescent Psychiatry and Psychotherapy, Fetscherstraße 74, 01307 Dresden, Germany. Electronic address: [email protected] , (Germany)
  • 3 University Hospital Erlangen, Department of Child and Adolescent Mental Health, Schwabachanlage 6 & 10, 91054 Erlangen, Germany. Electronic address: [email protected] , (Germany)
  • 4 University Hospital Erlangen, Department of Child and Adolescent Mental Health, Schwabachanlage 6 & 10, 91054 Erlangen, Germany. Electronic address: [email protected] , (Germany)
  • 5 University Hospital Erlangen, Department of Child and Adolescent Mental Health, Schwabachanlage 6 & 10, 91054 Erlangen, Germany. Electronic address: [email protected] , (Germany)
  • 6 University Hospital Erlangen, Department of Child and Adolescent Mental Health, Schwabachanlage 6 & 10, 91054 Erlangen, Germany. Electronic address: [email protected] , (Germany)
  • 7 University Hospital Erlangen, Department of Child and Adolescent Mental Health, Schwabachanlage 6 & 10, 91054 Erlangen, Germany. Electronic address: [email protected] , (Germany)
  • 8 University Hospital Erlangen, Department of Obstetrics and Gynecology, Universitätsstraße 21-23, 91054 Erlangen, Germany; Department of Perinatal Medicine and Obstetrics, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany. Electronic address: [email protected] , (Germany)
  • 9 University Hospital Erlangen, Department of Obstetrics and Gynecology, Universitätsstraße 21-23, 91054 Erlangen, Germany. Electronic address: [email protected] , (Germany)
  • 10 University Hospital Erlangen, Department of Obstetrics and Gynecology, Universitätsstraße 21-23, 91054 Erlangen, Germany. Electronic address: [email protected] , (Germany)
  • 11 University Hospital Erlangen, Department of Psychiatry and Psychotherapy, Schwabachanlage 6, 91054 Erlangen, Germany. Electronic address: [email protected] , (Germany)
  • 12 University Hospital Erlangen, Department of Child and Adolescent Mental Health, Schwabachanlage 6 & 10, 91054 Erlangen, Germany. Electronic address: [email protected] , (Germany)
  • 13 University Hospital Erlangen, Department of Child and Adolescent Mental Health, Schwabachanlage 6 & 10, 91054 Erlangen, Germany; kbo-Heckscher-Klinikum, Deisenhofener Str. 28, 81539 München, Germany. Electronic address: [email protected] , (Germany)
  • 14 University Hospital Erlangen, Department of Child and Adolescent Mental Health, Schwabachanlage 6 & 10, 91054 Erlangen, Germany. Electronic address: [email protected] , (Germany)
  • 15 University Hospital Erlangen, Department of Child and Adolescent Mental Health, Schwabachanlage 6 & 10, 91054 Erlangen, Germany. Electronic address: [email protected] , (Germany)
Type
Published Article
Journal
Physiology & behavior
Publication Date
Jun 20, 2019
Volume
209
Pages
112584–112584
Identifiers
DOI: 10.1016/j.physbeh.2019.112584
PMID: 31228497
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The aim of the present work is to investigate the association of salivary and cumulative cortisol levels with emotional and behavioral symptoms in a Franconian Cognition and Emotion Studies (FRANCES) general population cohort of 158 6- to 9 year old children. Salivary cortisol values were measured by one-day diurnal cortisol profile, whereas cumulative cortisol was estimated via one-month hair cortisol concentrations (rHCC). Nearly all significant associations of clinical symptoms with child cortisol indices were age dependent: We report emotional symptoms being associated with lower rHCC in younger children (6.06-7.54 years). In older children (7.55-9.41 years) behavioral problems were further associated with higher rHCC and lower salivary cortisol awakening responses. In summary, child clinical symptoms were stronger associated with markers of hair cortisol compared to salivary cortisol. To picture developmental mechanisms, we suggest longitudinal designs for cortisol measures of stress systems in children and adolescents. Copyright © 2019 Elsevier Inc. All rights reserved.

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