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Salbutamol metered-dose inhaler with spacer for hyperkalemia: how fast? How safe?

Authors
Type
Published Article
Journal
Chest
Publication Date
Volume
115
Issue
3
Pages
617–622
Identifiers
PMID: 10084465
Source
Medline
License
Unknown

Abstract

Salbutamol inhalation of 1,200 microg, using an MDI-S, has a relatively rapid onset of action that induces a consistent reduction in serum potassium levels, starting 3 to 5 min following delivery. Unexpectedly, a paradoxical elevation was detected in serum potassium levels in the first minutes following inhalation. This effect, although minor (0.15 mEq/L above baseline), may cast some doubt on the role of salbutamol inhalation as the first treatment for excessive hyperkalemia.

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