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Safety of Oral Dofetilide Reloading for Treatment of Atrial Arrhythmias.

Authors
  • Cho, Jae Hyung1
  • Youn, So Jin1
  • Moore, JoEllyn C1
  • Kyriakakis, Roxanne1
  • Vekstein, Carolyn1
  • Militello, Michael1
  • Poe, Stacy M1
  • Wolski, Kathy1
  • Tchou, Patrick J1
  • Varma, Niraj1
  • Niebauer, Mark J1
  • Bhargava, Mandeep1
  • Saliba, Walid I1
  • Wazni, Oussama M1
  • Lindsay, Bruce D1
  • Wilkoff, Bruce L1
  • Chung, Mina K2
  • 1 From the Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, OH. Current address for Dr Cho: Cedars-Sinai Heart Institute, Los Angeles, CA. Current address for Dr Youn: Department of Internal Medicine, Cleveland Clinic, OH. Current address for Dr Moore: Minneapolis Heart Institute, Abbott Northwestern Hospital, MN. Current address for R. Kyriakakis: College of Medicine, Medical University of South Carolina, Charleston. Current address for C. Vekstein: Dana-Farber Cancer Institute, Boston, MA. Current address for M. Militello: Pharmacy Department, Cleveland Clinic, OH.
  • 2 From the Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, OH. Current address for Dr Cho: Cedars-Sinai Heart Institute, Los Angeles, CA. Current address for Dr Youn: Department of Internal Medicine, Cleveland Clinic, OH. Current address for Dr Moore: Minneapolis Heart Institute, Abbott Northwestern Hospital, MN. Current address for R. Kyriakakis: College of Medicine, Medical University of South Carolina, Charleston. Current address for C. Vekstein: Dana-Farber Cancer Institute, Boston, MA. Current address for M. Militello: Pharmacy Department, Cleveland Clinic, OH. [email protected]
Type
Published Article
Journal
Circulation Arrhythmia and Electrophysiology
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Oct 01, 2017
Volume
10
Issue
10
Identifiers
DOI: 10.1161/CIRCEP.117.005333
PMID: 29038104
Source
Medline
Keywords
License
Unknown

Abstract

Although no TdP occurred in patients admitted to reload dofetilide at the same dose as previously tolerated, dosage adjustments or discontinuation was frequent and support the need for hospitalization for dofetilide reloading. Patients admitted for reloading with a higher dose tended to be at higher risk for TdP than patients reloaded at a prior tolerated dose.

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