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Safety evaluation of topically applied amitriptyline in porcine full-thickness wounds.

Authors
  • Pomahac, Bohdan
  • Zuhaili, Bara
  • Kudsi, Yusef
  • Bleiziffer, Oliver
  • Velander, Patrik
  • Eriksson, Elof
  • Gerner, Peter
Type
Published Article
Journal
Regional Anesthesia and Pain Medicine
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Jan 01, 2007
Volume
32
Issue
5
Pages
377–381
Identifiers
PMID: 17961834
Source
Medline
License
Unknown

Abstract

Amitriptyline at the concentrations of 0.0625% and 0.125% applied daily via chambers covering wounds in a full-thickness pig excision model has no overt toxic effect on wound healing as measured by wound contraction and histological assessment.

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