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Safety and efficacy of a new spot-on formulation of selamectin plus sarolaner in the treatment and control of naturally occurring flea infestations in cats presented as veterinary patients in Australia

Authors
  • Packianathan, Raj1
  • Pittorino, Melissa2
  • Hodge, Andrew1
  • Bruellke, Natalie1
  • Graham, Kelly3
  • 1 Zoetis Australia Research and Manufacturing Pty Ltd, Level 6, 5 Rider Boulevard, Rhodes, NSW, 2138, Australia , Rhodes (Australia)
  • 2 Eurofins Animal Health, Unit, F10, 16 Mars Road, Lane Cove West, NSW, 2066, Australia , Lane Cove West (Australia)
  • 3 Zoetis, Level 6, 5 Rider Boulevard, Rhodes, NSW, 2138, Australia , Rhodes (Australia)
Type
Published Article
Journal
Parasites & Vectors
Publisher
Springer (Biomed Central Ltd.)
Publication Date
May 06, 2020
Volume
13
Issue
1
Identifiers
DOI: 10.1186/s13071-020-04099-x
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundThe safety and efficacy of a new spot-on formulation of selamectin plus sarolaner were evaluated for the treatment and control of natural flea infestations on cats in two non-randomised, multi-centre clinical trials conducted in 8 different locations in Queensland, Australia.MethodsOne hundred and four cats from 65 different households were enrolled across the two studies. Demographic characteristics of cats in the two studies were similar. The new spot-on formulation of selamectin and sarolaner was administered topically once a month for 3 consecutive months at a minimum dosage of 6 mg/kg selamectin (dose range 6–12 mg/kg) plus 1 mg/kg sarolaner (dose range 1–2 mg/kg). Cats were dosed on Days 0 (pre-treatment), 30 and 60 and physical examinations and flea counts were conducted on Days 0, 30, 60 and 90. Efficacy assessments were based on the percentage reduction in live flea counts post-treatment compared to Day 0.ResultsIn Study A, at enrolment, primary cats had flea counts ranging from 6 to 107 (arithmetic mean 21.0). The selamectin and sarolaner spot-on formulation resulted in arithmetic mean efficacy of 98.0%, 100% and 100% on Days 30, 60 and 90, respectively. In Study B, at enrolment, primary cats had flea counts ranging from 6 to 22 (arithmetic mean 10.0). The selamectin and sarolaner spot-on formulation resulted in arithmetic mean efficacy of 99.7%, 100% and 100% on Days 30, 60 and 90, respectively.ConclusionsThe new spot-on formulation of selamectin plus sarolaner topically administered at monthly intervals at the minimum dosage of 6.0 mg/kg selamectin and 1.0 mg/kg sarolaner was safe and highly effective against natural infestations of fleas under a range of geographical conditions, representative of both tropical and subtropical regions of Australia.

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