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Safety and efficacy of direct-acting antivirals for chronic hepatitis C in patients with chronic kidney disease

Authors
  • Iliescu, Elena Laura1
  • Mercan-Stanciu, Adriana1
  • Toma, Letitia1
  • 1 Fundeni Clinical Institute, Bucharest, 022328, Romania , Bucharest (Romania)
Type
Published Article
Journal
BMC Nephrology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 16, 2020
Volume
21
Issue
1
Identifiers
DOI: 10.1186/s12882-020-1687-1
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundThis is a real-world evidence study that aims to analyze the efficacy, tolerability and safety profile of paritaprevir/ombitasvir/ritonavir and dasabuvir, in patients with renal impairment.MethodsWe conducted an observational prospective study, on 232 patients with chronic kidney disease, undergoing treatment with paritaprevir/ombitasvir/ritonavir and dasabuvir, for chronic hepatitis C infection - genotype 1b. Renal and liver function were assessed at the beginning of therapy, monthly during treatment and three months after therapy completion.ResultsAll patients achieved sustained virologic response. Common side effects were nausea, fatigue and headache. Close monitoring of tacrolimus blood levels and dose reduction was required in kidney transplant recipients.ConclusionsHCV therapy in the setting of renal dysfunction has always been a challenging topic. Direct-acting antivirals have shown promising effects, demonstrating good tolerance and efficacy in patients with HCV infection and renal impairment. Sustained virologic response within our study population was 100%.

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