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Safety and effectiveness of U-500 insulin therapy in patients with insulin-resistant type 2 diabetes mellitus.

Authors
  • Quinn, Suzanne L
  • Lansang, M Cecilia
  • Mina, Deanna
Type
Published Article
Journal
Pharmacotherapy
Publication Date
Jul 01, 2011
Volume
31
Issue
7
Pages
695–702
Identifiers
DOI: 10.1592/phco.31.7.695
PMID: 21923457
Source
Medline
License
Unknown

Abstract

In patients with insulin-resistant diabetes who have requirements of more than 200 units/day or 100 units/injection, use of U-500 regular insulin provided the same or better glucose control compared with U-100 insulin, with fewer daily injections and reduced injection volume. Although this drug represents an excellent treatment option, its safe use requires an experienced physician, a motivated and cooperative patient, and a dynamic diabetes management team.

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