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S1P/S1P Receptor Signaling in Neuromuscolar Disorders

Authors
  • Meacci, Elisabetta1, 2
  • Garcia-Gil, Mercedes3
  • 1 Clinical Biochemistry and Clinical Molecular Biology Unit, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
  • 2 Interuniversity Institute of Myology, University of Firenze, 50134 Firenze, Italy
  • 3 Interdepartmental Research Center “Nutraceuticals and Food for Health”, University of Pisa, 56127 Pisa, Italy
Type
Published Article
Journal
International Journal of Molecular Sciences
Publisher
MDPI AG
Publication Date
Dec 17, 2019
Volume
20
Issue
24
Identifiers
DOI: 10.3390/ijms20246364
PMID: 31861214
PMCID: PMC6941007
Source
PubMed Central
Keywords
License
Green

Abstract

The bioactive sphingolipid metabolite, sphingosine 1-phosphate (S1P), and the signaling pathways triggered by its binding to specific G protein-coupled receptors play a critical regulatory role in many pathophysiological processes, including skeletal muscle and nervous system degeneration. The signaling transduced by S1P binding appears to be much more complex than previously thought, with important implications for clinical applications and for personalized medicine. In particular, the understanding of S1P/S1P receptor signaling functions in specific compartmentalized locations of the cell is worthy of being better investigated, because in various circumstances it might be crucial for the development or/and the progression of neuromuscular diseases, such as Charcot–Marie–Tooth disease, myasthenia gravis, and Duchenne muscular dystrophy.

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