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S100A14 protein as diagnostic and prognostic marker in hepatocellular carcinoma

Authors
  • Mohamed, Basma Fathy1
  • Serag, Waleed Mohamed2
  • Abdelal, Reda Mahamoud3
  • Elsergany, Heba Fadl4
  • 1 Biochemist, Suez Hospital for Health Insurance, Suez, Egypt , Suez (Egypt)
  • 2 Suez University, Suez, Egypt , Suez (Egypt)
  • 3 Professor of Organic Chemistry, Chemistry Department, Faculty of Science, Suez, Egypt , Suez (Egypt)
  • 4 Assistant professor of Hepatology and Gastroenterology, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt , Cairo (Egypt)
Type
Published Article
Journal
Egyptian Liver Journal
Publisher
Springer Berlin Heidelberg
Publication Date
Dec 20, 2019
Volume
9
Issue
1
Identifiers
DOI: 10.1186/s43066-019-0015-6
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundProtein S100A14 has recently been implicated in the progress of several types of cancers. This study aimed to investigate the clinical significance of S100A14 in the diagnosis of hepatocellular carcinoma (HCC).ResultsS100A14 was significantly elevated in the HCC group. A cut-off value for serum S100A14 between the HCC group and cirrhosis group is > 0.47 with a sensitivity of 100% and specificity of 88.57%. S100A14 level was a significant diagnostic factor for HCC and a good reference for HCC progression.ConclusionThese results suggest that S100A14 is a good diagnostic marker for HCC.

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