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An S100 negative granular cell tumor with malignant potential: report of a case.

Authors
  • Schoedel, K E
  • Bastacky, S
  • Silverman, A
Type
Published Article
Journal
Journal of the American Academy of Dermatology
Publisher
Elsevier
Publication Date
Nov 01, 1998
Volume
39
Issue
5 Pt 2
Pages
894–898
Identifiers
PMID: 9810925
Source
Medline
License
Unknown

Abstract

Malignant granular cell tumors are rare, but exhibit typical histologic, immunohistochemical, and electron microscopic features that also characterize their benign counterparts. Although most granular cell tumors are S100 protein positive, we report an S100 negative granular cell tumor with histopathologic evidence supporting malignancy. This tumor is best categorized as a malignant granular cell tumor rather than a granular cell variant of a malignant histiocytic, mesenchymal, or epithelial neoplasm. A multidisciplinary approach is essential to diagnosis.

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