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S-aryl cysteine S,S-dioxides as inhibitors of mammalian kynureninase.

Authors
  • Drysdale, M J
  • Reinhard, J F
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Jan 20, 1998
Volume
8
Issue
2
Pages
133–138
Identifiers
PMID: 9871640
Source
Medline
License
Unknown

Abstract

A series of 2-amino-S-aryl cysteine S,S-dioxides have been synthesised and shown to inhibit kynureninase an important enzyme in the biosynthesis of the known excitotoxic moiety quinolinic acid. The most potent of these, 2-amino-5-methyl-S-phenyl cysteine S,S-dioxide 6d, inhibits interferon-gamma induced synthesis of quinolinic acid in human macrophages.

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